A Location Based Value Prediction for Quality of Web Service

The number of web services with functionality increases, the service users usually depends on web recommendation systems. Now a days the service users pay more importance on non functional properties which are also known as Quality of Service (QoS) while finding and selecting appropriate web services. Collaborative filtering approach predicts the QoS values of the web services effectively. Existing recommendation systems rarely consider the personalized influence of the users and services in determining the similarity between users and services. The proposed system is a ranking oriented hybrid approach which integrates user-based and item-based QoS predictions. Many of the non-functional properties depends on the user and the service location. The system thus employs the location information of users and services in selecting similar neighbors for the target user and service and thereby making personalized service recommendation for service users

Formulation and evaluation of oxymetazoline hydrochloride nasal gels

The main intend of the implement sniff out formulate and evaluate oxymetazoline nasal gels. To achieve more persistent blood levels with decrease dosage of medicine by extended drug evidence and by passing hepatic initially cross metabolism and body including inferable disgrace. Mod FTIR & DSC spectra there is not any discrepancein the seam clean medicine, polymers & lipids. The Carbopol consisting of reinforce precail eventual scintillating moreover transparent Poloxamer, Hydroxy Propyl Methyl cellulose gels crop up prospective lucent as a consequence frosted slimy. The pH value of all developed formulations of gels (ONGF1-ONGF8) was in the range of 6.2 to 6.9. Spreadability of gels was in the range 19.51 - 33.91 g.cm/sec, The Viscosity of various formulated gels was found in range of 8628 to 9622 centipoises. The percentage drug content of all prepared gel formulations were found to be in the range of 78.53 to 98.56 %. The gel strength of all prepared formulations of gels was found to be in the range of 69 to 96 %. In-vitro diffusion drug release of Oxymetazoline Hydrochloride of nasal gels ONGF1 shows the 95% drug release. The release order kinetics shows all the formulations ONGF1 to ONGF8 formulations were followed Korsemeyer-Peppas with correlation coefficient R2=0.8969 & 0.2692 respectively. ONGF1 formulation follows both Zero order and Korsmeyer-Peppas models, it indicates diffusion release mechanism followed by non-fickian transport. Keywords: Nasal, gels, Oxymetazoline, In vitro diffusion, Carbopol

Potential for Enhancing Farmer Income in Semi-Arid Telangana: A Multi-model Systems Approach

This paper addresses the question: how do interventions in natural resource management, agronomy and livestock integration influence whole-farm bio-economic outcomes. The proposed interventions are modelled for farming systems in Telangana considering labour supply, consumption and market prices using the integrated analysis tool (IAT). The study is based on data collected from a random sample of 100 households in the Waddeman village of Bijinapalli mandal of Mahabubnagar district and was undertaken in 2016–2017. The study finds that simple interventions like in-situ soil moisture conservation and adoption of recommended level of nitrogen fertiliser on crops could increase whole-farm net returns by 7 per cent and 12 per cent during normal and drought years, respectively. Intensification of farming systems through replacing low-yielding cows and buffaloes with high-yielding showed increased net returns of 20–57 per cent during normal years and 35–136 per cent during drought years. These studies using system analysis tools will help researchers and extension agents to effectively evaluate a range of strategies exploring system intensification across diverse contexts for designing better livelihood improvement pathways

Respiratory support in patients with severe COVID-19 in the International Severe Acute Respiratory and Emerging Infection (ISARIC) COVID-19 study: a prospective, multinational, observational study

Background: Up to 30% of hospitalised patients with COVID-19 require advanced respiratory support, including high-flow nasal cannulas (HFNC), non-invasive mechanical ventilation (NIV), or invasive mechanical ventilation (IMV). We aimed to describe the clinical characteristics, outcomes and risk factors for failing non-invasive respiratory support in patients treated with severe COVID-19 during the first two years of the pandemic in high-income countries (HICs) and low middle-income countries (LMICs). Methods: This is a multinational, multicentre, prospective cohort study embedded in the ISARIC-WHO COVID-19 Clinical Characterisation Protocol. Patients with laboratory-confirmed SARS-CoV-2 infection who required hospital admission were recruited prospectively. Patients treated with HFNC, NIV, or IMV within the first 24 h of hospital admission were included in this study. Descriptive statistics, random forest, and logistic regression analyses were used to describe clinical characteristics and compare clinical outcomes among patients treated with the different types of advanced respiratory support. Results: A total of 66,565 patients were included in this study. Overall, 82.6% of patients were treated in HIC, and 40.6% were admitted to the hospital during the first pandemic wave. During the first 24 h after hospital admission, patients in HICs were more frequently treated with HFNC (48.0%), followed by NIV (38.6%) and IMV (13.4%). In contrast, patients admitted in lower- and middle-income countries (LMICs) were less frequently treated with HFNC (16.1%) and the majority received IMV (59.1%). The failure rate of non-invasive respiratory support (i.e. HFNC or NIV) was 15.5%, of which 71.2% were from HIC and 28.8% from LMIC. The variables most strongly associated with non-invasive ventilation failure, defined as progression to IMV, were high leukocyte counts at hospital admission (OR [95%CI]; 5.86 [4.83–7.10]), treatment in an LMIC (OR [95%CI]; 2.04 [1.97–2.11]), and tachypnoea at hospital admission (OR [95%CI]; 1.16 [1.14–1.18]). Patients who failed HFNC/NIV had a higher 28-day fatality ratio (OR [95%CI]; 1.27 [1.25–1.30]). Conclusions: In the present international cohort, the most frequently used advanced respiratory support was the HFNC. However, IMV was used more often in LMIC. Higher leucocyte count, tachypnoea, and treatment in LMIC were risk factors for HFNC/NIV failure. HFNC/NIV failure was related to worse clinical outcomes, such as 28-day mortality. Trial registration This is a prospective observational study; therefore, no health care interventions were applied to participants, and trial registration is not applicable

The value of open-source clinical science in pandemic response: lessons from ISARIC

International audienc